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Cooperative effects of ATP and voltage sensors in the KATP channel.
The ATP-binding sites in the sulfonylurea (SU) receptors are suggested to bind ATP to inhibit the channel, but on the basis of biochemical evidence, the precise molecular mechanism of this inhibition has not been established. Recent reports in the literature suggest that cytoplasmic ATP gates the pancreatic KATP channel, although the molecular details of this interaction remain to be elucidated. This report ec5d62056f greevol
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